Are herbs safe at high doses?

Not always.

A herb with a broad therapeutic range is safe. That means the difference between the dose that has a medicinal action and a dose that can give side effects is very large.  Most herbs have an extremely broad therapeutic range. It is very difficult or even impossible to take a toxic dose of most herbs. Chamomile, for example, can be taken in small or large quantities with no adverse effects.

On the other hand:

There are herbs that must be used with caution because their therapeutic range is narrow. For example, Lily of the Valley affects the heart in a similar way to Foxglove which is poisonous.  Only a little Lily of the Valley is needed to have a beneficial effect, too much would be toxic so it is important to make sure an accurate dose is taken.  A more common example of this is coffee – which can make us feel jittery and anxious if we drink too much.